A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity

Darnis, Deny Susanti and Attoumani, Nissad and Bakhtiar, M. Taher and Rezali, Mohd Fazlin and Sohrab, Md Hossain and Hasan, Choudhury Mahmood and Zakaria, Zainul Amiruddin (2018) A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity. Natural Product Sciences, 24 (1). pp. 47-53. ISSN 1226-3907 E-ISSN 2288-9027

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Abstract

Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 µg/ml MIC value. Compound 2 also inhibits S. aureus with 25 µg/ml MIC value.

Item Type:	Article (Journal)
Additional Information:	5641/63468
Uncontrolled Keywords:	Calophyllum symingtonianum, Guttiferae, Coumarins, Antibacterial.
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	30 Apr 2018 11:34
Last Modified:	30 Apr 2018 11:34
URI:	http://irep.iium.edu.my/id/eprint/63468

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