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Model of critical size defect in the New Zealand White rabbit's tibia

Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Sharifudin, Mohd Ariff and Che Ahmad, Aminudin and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2018) Model of critical size defect in the New Zealand White rabbit's tibia. The International Medical Journal Malaysia, 17 (1). pp. 13-18. E-ISSN 1823-4631

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Abstract

Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits.

Item Type: Article (Journal)
Additional Information: 4820/63258
Uncontrolled Keywords: New Zealand White rabbit, critical size defect, surgical approach, bone healing, tibia
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: AP Dr Zamzuri Zakaria
Date Deposited: 03 Apr 2018 15:01
Last Modified: 31 Oct 2018 14:17
URI: http://irep.iium.edu.my/id/eprint/63258

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