Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

Awaad, Amani Shafeek and Alafeefy, Ahmed Mahmoud and Alasmary, Fatmah A.S. and El-Meligy, Reham M. and Zain, Mohamed E. and Alqasoumi, Saleh Ibrahim (2017) Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity. Saudi Pharmaceutical Journal, 25 (7). pp. 967-971. ISSN 1319-0164

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Abstract

A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging.

Item Type:	Article (Journal)
Additional Information:	7668/62988
Uncontrolled Keywords:	Natural products hybrid; In-vitro; Anti-Helicobacter pylori; mino acid; Sulfanilamide; Anti-ulcerogenic agent
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Ahmed Alafeefy
Date Deposited:	10 Apr 2018 16:54
Last Modified:	21 Jun 2018 10:44
URI:	http://irep.iium.edu.my/id/eprint/62988

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