Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution

Mohammad, Khairool Azizul and Abd Rahim, Syarifah and Abu Bakar, Mohd Rushdi (2017) Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution. Journal of Thermal Analysis and Calorimetry, 130 (3). pp. 1663-1669. ISSN 1388-6150 E-ISSN 1588-2926

	PDF (Evidence from publishers' website for MYRA) - Published Version Restricted to Repository staff only Download (180kB) | Request a copy
Preview	PDF (scopus) - Supplemental Material Download (483kB) | Preview
	PDF (Article) - Published Version Restricted to Repository staff only Download (642kB) | Request a copy
	PDF - Supplemental Material Restricted to Registered users only Download (84kB) | Request a copy

Abstract

This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method.

Item Type:	Article (Journal)
Additional Information:	4033/62951
Uncontrolled Keywords:	Carbamazepine; Co-crystal; KBHR; Kinetics; MSZW Nucleation
Subjects:	T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Mohd Rushdi Abu Bakar
Date Deposited:	24 Dec 2018 09:50
Last Modified:	15 Jul 2019 09:59
URI:	http://irep.iium.edu.my/id/eprint/62951

Actions (login required)

View Item