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Selected natural agents used for cholesterol controls

Abdul Latif, Nurul Hazwani and Bakhtiar, M. Taher and Md Jaffri, Juliana and Amri, Mohamad Shahreen and Abdul Kudos, Muhammad Badri and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti (2018) Selected natural agents used for cholesterol controls. Nutrition & Food Science, 48 (2). pp. 301-317. ISSN 0034-6659

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Abstract

Purpose – Various studies suggest that some of natural agents create a specific action of hypocholesterolemic effect. Considering this fact, the aim of this paper is to work on describing selected natural agents that may reduce cholesterol concentrations by different mechanism of actions. Design/methodology/approach – The advantages, phytochemical components and the mechanisms of the agents were reviewed and supported from the findings of the in vitro, double-blind and clinical studies from published journals, books and articles. The journals used in this review were published between 1987 and 2016, and are available from PubMed, ScienceDirect and Google Scholar. Findings – Plant stanols and sterols, turmeric, fenugreek, avocado, tomato, artichoke, red yeast rice and garlic showed a positive effect in maintaining cholesterol levels by specific mechanisms or actions. These agents each had a specific action in creating a hypocholesterolemic effect either by inhibition of the enzyme significant to the synthesis process, disturbing the absorption of cholesterol, conversion of cholesterol to other related forms and through the reduction of the oxidative stress. Research limitations/implications – However, this field still needs more studies as, currently, there is not any detailed information regarding the main active ingredients responsible for the mechanism to reduce cholesterol levels in humans. Originality/value – This paper enlightens the authors’ understanding of some natural agents that have the potential to be used in controlling cholesterol.

Item Type: Article (Journal)
Additional Information: 5209/62827
Uncontrolled Keywords: Health foods, Food
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Muhammad Taher
Date Deposited: 05 Apr 2018 16:42
Last Modified: 26 Apr 2018 16:06
URI: http://irep.iium.edu.my/id/eprint/62827

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