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Serum leptin might be causally correlated to invasive ductal breast carcinoma

Al-Shibli, Saad M. and Amjad, Nasser Muhammad and Al-Kubaisi, Muna Khaleel Dheyab and Harun, Norra and Nafie, Emad M. and Mizan, Shaikh (2018) Serum leptin might be causally correlated to invasive ductal breast carcinoma. Journal of Clinical & Experimental Oncology, 7 (1). pp. 1-5. ISSN 2324-9110

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Introduction: Leptin, the hormone secreted from white adipose tissue is suspected of being a causative factor in tumorigenesis invarious tissues. Thus it might be a link between obesity and breastcancer. Objectives: In this project we tried to study causative association ofobesity and serum leptin with invasive ductal breast cancer (IDC) in a sample of Malaysian population. Methods: We measured various obesity parameters, and estimated serum leptin levels in a group of healthy control and IDC patients.After confirming diagnosis by standard histopathological methods, serum leptin levels were estimated using ELISA. Both the pre-and postoperative leptin levels were measured with the Patient group. Results: The difference between the serum leptin levels of the Control and the Patient group were highly significant with a P value of < 0.001. There was no significant difference in the serum leptin level between the pre and post-operative states in the IDC patients (P=0.414).There was a significant positive correlation between the serum leptin level and the Body Mass Index (BMI) with the Control group (rs =0.598, P < 0.01), however, the breast cancer cases showed a very weakly positive correlation (r= 0.217, P > 0.05). Conclusion: Since high serum leptin in IDC patients persists unabated in the post-operative state, we infer that the source of leptin in these cases cannot be the breast cancer tissue itself and leptin cannot be a marker for breast cancer. Highly significant association between serum leptin and IDC patients suggests that leptin in serum might play a causative role in the tumorigenesis of breast cancer, and it might be an important connection between obesity and breast cancer. Therefore, leptin signal transduction pathway might be a prospective therapeutic target in the treatment and prevention of IDC.

Item Type: Article (Journal)
Additional Information: 6204/62637
Uncontrolled Keywords: Leptin; Serum leptin; Invasive ductal carcinoma; Breast cancer;obesity
Subjects: R Medicine > RD Surgery
R Medicine > RG Gynecology and obstetrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Obstetric & Gynecology
Kulliyyah of Medicine > Department of Surgery
Kulliyyah of Science > Department of Biomedical Science
Depositing User: salina mohammad
Date Deposited: 03 Apr 2018 16:32
Last Modified: 03 Apr 2018 16:32
URI: http://irep.iium.edu.my/id/eprint/62637

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