Effects of solvents on polymorphism and shape of mefenamic acid crystals

Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati and Che Man, Rohaida and Sulaiman, Siti Zubaidah and Mohd Arshad, Zatul Iffah and Md. Shaarani, Shalyda (2018) Effects of solvents on polymorphism and shape of mefenamic acid crystals. In: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017)., 6-7 Dec,2017, Penang.

	PDF - Published Version Restricted to Registered users only Download (1MB) | Request a copy
	PDF (Scopus) - Supplemental Material Restricted to Registered users only Download (491kB) | Request a copy

Abstract

Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	4033/62633
Uncontrolled Keywords:	solvents, polymorphism, mefenamic acid crystals
Subjects:	T Technology > T Technology (General) T Technology > T Technology (General) > T175 Industrial research. Research and development
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	12 Apr 2018 09:56
Last Modified:	10 Jul 2018 17:03
URI:	http://irep.iium.edu.my/id/eprint/62633

Actions (login required)

View Item