Animal models and natural products to investigate in vivo and in vitro antidiabetic activity

Hasan, Md. Mahmudul (Stu) and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Tunna, Tasnuva Sarwar (2018) Animal models and natural products to investigate in vivo and in vitro antidiabetic activity. Biomedicine & Pharmacotherapy, 101. pp. 833-841. ISSN 0753-3322

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Abstract

Diabetes mellitus is a chronic disease which has high prevalence. The deficiency in insulin production or impaired insulin function is the underlying cause of this disease. Utilization of plant sources as a cure of diabetes has rich evidence in the history. Recently, the traditional medicinal plants have been investigated scientifically to understand the underlying mechanism behind antidiabetic potential. In this regard, a substantial number of in vivo and in vitro models have been introduced for investigating the bottom-line mechanism of the antidiabetic effect. A good number of methods have been reported to be used successfully to determine antidiabetic effects of plant extracts or isolated compounds. This review encompasses all the possible methods with a list of medicinal plants which may contribute to discovering a novel drug to treat diabetes more efficaciously with the minimum or no side effects.

Item Type:	Article (Review)
Additional Information:	4921/62580
Uncontrolled Keywords:	Animal model, diabetes, medicinal plants, flavonoids, diabetes mechanisms
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	30 Mar 2018 12:38
Last Modified:	04 Jan 2019 10:50
URI:	http://irep.iium.edu.my/id/eprint/62580

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