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A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

Alhassan, Alhassan Muhammad and Ahmed, Qamar Uddin and Latip, Jalifah and Shah, Syed Adnan Ali (2019) A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity. Natural Product Research, 33 (1). pp. 1-8. ISSN 1478-6427 (In Press)

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Abstract

The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential.

Item Type: Article (Journal)
Additional Information: 4921/62515
Uncontrolled Keywords: Tetracera indica; dilleniaceae; sulphated flavonoid; alphaglucosidase inhibitory activity; docking
Subjects: Q Science > QE Geology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy
Depositing User: Dr Qamar Uddin Ahmed
Date Deposited: 28 Mar 2018 09:38
Last Modified: 14 Jun 2019 16:23
URI: http://irep.iium.edu.my/id/eprint/62515

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