Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation

Othman, Liyana Zafirah and Mohd Nawi, Mohamed Sufian and Abul Bashar Mohammed, Helaluddin and Elsayed, Tarek Mohamed Ali (2017) Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation. In: International Malaysian French Scientific Conference 2017, 18th-19th December 2017, Kuala Lumpur. (Unpublished)

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Abstract

Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as retardants for the sustained release gliclazide tablet. In this study, sustained release 60 mg gliclazide tablets were formulated with different ratios and content of xanthan gum and HPMC. The tablets were produced by wet granulation and semi-automatic tableting process. The content variation, weight variation, hardness, and friability of the tablet met the specification by British Pharmacopoeia. In vitro dissolution profiles of the tablets were compared with the commercially available sustained release 60 mg gliclazide tablet. Keywords: Gliclazide; sustained release; xanthan gum; HPMC

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5956/62416
Uncontrolled Keywords:	Gliclazide; sustained release; xanthan gum; HPMC
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Mohamed Sufian Mohd Nawi
Date Deposited:	29 Mar 2018 09:43
Last Modified:	29 Mar 2018 09:43
URI:	http://irep.iium.edu.my/id/eprint/62416

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