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The release profiles of Baccaurea angulata extract from various gelling agents

Sukmasari, Susi and Abdul Qader, Omar Abdul Jabbar and Abdul Rahman, Mohammad Nasrin and Ibrahim, Muhammad and Doolaanea, Abd Almonem (2018) The release profiles of Baccaurea angulata extract from various gelling agents. Journal of Pharmaceutical Sciences and Research, 10 (1). pp. 45-50. ISSN 0975-1459

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Abstract

This study investigates the release profiles of Baccaurea angulata extracts incorporated in carbopol, guar gum, and konjac gum. Franz cell diffusion was run for 24h for finite dosing, and 6h for infinite dosing. From finite dosing, carbopol had the highest cumulative amount permeated, (75.75±1.18% content release) compared to guar gum and konjac gum (p<0.05). Carbopol exhibited the fastest release profile with the highest mean flux (29.04±0.74μg/cm2/h) (p<0.05) permeated within the first 0.75h. Konjac gum had faster release behavior compared to guar gum. However, the amount of content release by guar gum was higher compared to konjac gum for the total of 24h (p<0.05). For infinite dosing, the cumulative amount of content released by carbopol was the highest (4095.97±38.70μg) compared to guar gum and konjac gum (p < 0.05). Steady state flux of carbopol was the highest (379.26±3.58 μg/cm2/h) compared to guar gum and konjac gum (p<0.05). Carbopol showed the highest permeability coefficient: 6.20×10-2cm/h compared to guar gum and konjac gum (p<0.05). Guar gum had higher values in all calculated elements compared to konjac gum, except that its content release was slower. Therefore, it is concluded that carbopol has the best release profile to be developed as Baccaurea angulata dental gel.

Item Type: Article (Journal)
Additional Information: 6171/61772
Uncontrolled Keywords: gels, Franz cell, release profile , Baccaurea angulata, drug delivery
Subjects: R Medicine > RK Dentistry
R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Dentistry > Paediatric Dentistry, Orthodontics & Dental Public Health
Depositing User: Dr. Susi Sukmasari
Date Deposited: 02 Feb 2018 11:20
Last Modified: 10 Aug 2018 16:32
URI: http://irep.iium.edu.my/id/eprint/61772

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