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Microencapsulation of fish oil using supercritical antisolvent process

Karim, Fahim Tamzeedul and Ghafoor, Kashif and Ferdosh, Sahena and Al-Juhaımı,, Fahad Y.I. and Ali, Md Eaqub and Yunus, Kamaruzzaman and Hamed, Mir Hoseini and Islam., Ashraful M.A and Asif, Muhammad Kamran and Sarker, Md Zaidul Islam (2017) Microencapsulation of fish oil using supercritical antisolvent process. Journal of Food and Drug Analysis, 25 (3). pp. 654-666.

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In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the opti-mum response value was evaluated at the conditions of temperature at 60 C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the optimum conditions, particle size of 58.35 mm was obtained. The surface morphology of the micronized fish oil was also evaluated using field emission scanning electron microscopy where it showed that particles formed spherical structures with no internal voids. Moreover, in vitro release of oil showed that there are significant differences of release percentage of oil between the formulations and the results proved that there was a significant decrease in the in vitro release of oil from the powder when the polymer concentration was high.

Item Type: Article (Journal)
Additional Information: 7165/61760
Uncontrolled Keywords: HPMC, microencapsulation, omega 3, supercritical antisolvent
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Science > Department of Plant Science
Depositing User: Dr. Sahena Ferdosh
Date Deposited: 01 Feb 2018 15:45
Last Modified: 01 Feb 2018 16:49
URI: http://irep.iium.edu.my/id/eprint/61760

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