The evaluation of physicochemical and anti-microbial properties of honey based hydrogel

Abdul Jalil, Mohd Azri and Kasmuri, Abdul Razak and Ab. Hadi, Hazrina (2017) The evaluation of physicochemical and anti-microbial properties of honey based hydrogel. Malaysian Journal of Pharmacy, 3 (1 (Supplement)). p. 25. ISSN 1675-3666

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Abstract

NTRODUCTION: Hydrogel possess a three-dimensional cross linked networks of hydrophilic polymers. Honey contain anti-microbial properties due to its peroxide and non-peroxide components.OBJECTIVES: To develop and characterize honey based hydrogel formulation and to evaluate its anti-microbial properties. METHODS: The hydrogel were developed by combining polyvinyl alcohol (PVA) and polyethylene glycol (PEG). 1% protein-free agar was added to the combination as well as honey according to their respective formulations. Then, the characterization tests consist of gel fraction, swelling ratio and water vapour transmission (WVTR) were conducted. For the antimicrobial evaluation, microbial limit test and agar diffusion test were conducted against Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS: For the gel fraction test, the control formulation was significantly (p<0.05) highest among the others; indicates that the PVA in this formulation was almost completely cross-linked. For the swelling ratio test, formulation 2 that contain 20% (w/v) honey was significantly (p<0.05) higher than the control and agar groups; indicates a higher water uptake occurred. The WVTR of formulation 2 was within the recommended range which is in between 80–105gm -2day -1. Formulation 5 with 40% (w/v) honey has shown anti-microbial effect towards Staphylococcus aureus. For microbial limit tests, all formulations showed the absence of bacteria in their respective surfaces.CONCLUSIONS: Formulation 2 demonstrated significantly better physicochemical properties but displaying no anti-microbial properties. However, formulation 5 showed an acceptable physicochemical properties but able to display a good anti-microbial properties. Therefore, formulation 5 will be selected for further studies. Keywords: hydrogel, honey, anti-microbial

Item Type:	Article (Meeting Abstract)
Additional Information:	3658/61756
Uncontrolled Keywords:	physicochemical, anti-microbial, honey based hydrogel
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Hazrina Ab Hadi
Date Deposited:	06 Feb 2018 13:03
Last Modified:	06 Feb 2018 13:03
URI:	http://irep.iium.edu.my/id/eprint/61756

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