Sepsis mortality score for the prediction of mortality in septic patients

Wan Mohd Shukeri, Wan Fadzlina and Md Ralib, Azrina and Abdullah, Norzamzila and Mat Nor, Mohd Basri (2018) Sepsis mortality score for the prediction of mortality in septic patients. Journal of Critical Care, 43. pp. 163-168. ISSN 0883-9441 E-ISSN 1557-8615

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Abstract

Purpose: To derive a prediction equation for 30-day mortality in sepsis using a multi-marker approach and compare its performance to the Sequential Organ Failure Assessment (SOFA) score. Methods: This study included 159 septic patients admitted to an intensive care unit. Leukocytes count, procalcitonin (PCT), interleukin-6 (IL-6), and paraoxonase (PON) and arylesterase (ARE) activities of PON-1 were assayed from blood obtained on ICU presentation. Logistic regression was used to derive sepsis mortality score (SMS), a prediction equation describing the relationship between biomarkers and 30-day mortality. Results: The 30-day mortality rate was 28.9%. The SMS was [еlogit(p)/(1 + еlogit(p))] × 100; logit(p) =0.74+ (0.004 × PCT)+(0.001 × IL-6)−(0.025 × ARE)−(0.059 × leukocytes count). The SMC had higher area under the receiver operating characteristic curve (95% Cl) than SOFA score [0.814 (0.736–0.892) vs. 0.767 (0.677–0.857)], but is not statistically significant.When the SMSwas added to the SOFA score, prediction of 30-day mortality improved compared to SOFA score used alone [0.845 (0.777–0.899), p=0.022]. Conclusions: A sepsismortality score using baseline leukocytes count, PCT, IL-6 and ARE was derived, which predicted 30-day mortality with very good performance and added significant prognostic information to SOFA score.

Item Type:	Article (Journal)
Additional Information:	3934/61635
Uncontrolled Keywords:	Sepsis; Leukocytes count; Interleukin-6; Procalcitonin Paraoxonase-1 Mortality
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Prof Azrina Md Ralib
Date Deposited:	30 Jan 2018 15:46
Last Modified:	26 Apr 2018 15:17
URI:	http://irep.iium.edu.my/id/eprint/61635

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