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Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital

Elnaem, Mohamed Hassan Abdelaziz and Nik Mohamed, Mohamad Haniki and Nazar, Amirul Hazim and Ibrahim, Rabiatul Nur Khaliesa (2017) Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital. Journal of Applied Pharmaceutical Science, 7 (12). 077-083. ISSN 2231-3354

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Background: There are raised concerns regarding the rational guidelines-based prescribing of proton pump inhibitors (PPIs) therapy in the hospital setting. Objective: To describe the current prescribing practice of PPIs among hospitalized patients in non-intensive care settings. Also, the study aimed to evaluate the appropriateness of the prescribed PPIs. Methods: A cross-sectional study was conducted in the medical ward of a tertiary hospital in the state of Pahang, Malaysia. A total of 153 medical records of non-critically-ill adult patients receiving PPI therapy were investigated. The assessment of PPI prescribing was performed referring to clinical guidelines and the list of PPI-approved indications. Results: The most frequently prescribed PPI regimen has been pantoprazole 40 mg OD. Approximately 34% of the prescribed regimens were considered to be appropriate as it was consistent with the clinical guidelines. However, about 31% of the prescribed PPIs did not have a clear indication. Moreover, the inappropriate use of PPIs was revealed in nearly 19% of the total PPIs prescriptions. Finally, 16% of the prescribed PPIs were in need of dosage adjustment due to the presence of drug-drug interactions with the concurrently used medications. Conclusion: Inappropriately prescribed PPIs are prevalent among non-critically ill-hospitalized adult patients in a Malaysian tertiary hospital. Initiatives for enforcing rational prescribing should focus on the proper documentation of evidence-based indications of PPIs in the medical records. There is a desperate need in the local setting for well-defined PPIs prescribing criteria. Future research should design and examine the impact of prescribing improvement interventions on the PPIs rational prescribing.

Item Type: Article (Journal)
Additional Information: 7472/61261
Uncontrolled Keywords: Proton pump inhibitors, Malaysia, prescribing patterns, Clinical practice guidelines, evaluation
Subjects: R Medicine > RC Internal medicine > RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Dr Mohamed Elnaem
Date Deposited: 11 Jan 2018 15:49
Last Modified: 15 Jul 2022 10:34
URI: http://irep.iium.edu.my/id/eprint/61261

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