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α-glucosidase inhibitors isolated from Mimosa pudica L.

Tasnuva, S. T. and Ahmed, Qamar Uddin and Ghafoor, Kashif and Ferdosh, Sahena and Jahurul, M. H. A. and Rukshana, A. H. and Md. Jaffri, Juliana and Y. Al-Juhaimi, Fahad and Jalifah, L. and Jalal, K. C. A. and Ali, Md. Eaqub and Sarker, Md Zaidul Islam (2017) α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research. pp. 1-6. ISSN 1478-6427 (In Press)

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Abstract

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.

Item Type: Article (Journal)
Additional Information: 4291/60959
Uncontrolled Keywords: Mimosa pudica; Fabaceae; α-glucosidase inhibitors
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr Qamar Uddin Ahmed
Date Deposited: 04 Jan 2018 11:53
Last Modified: 05 Aug 2019 10:28
URI: http://irep.iium.edu.my/id/eprint/60959

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