Rheological characterization of gelling polymers for pharmaceutical dosage forms

Abdul Qader, Omar Abdul Jabbar and Doolaanea, Abd Almonem and Abdul Rahman, Mohammad Nasrin and Sukmasari, Susi and Ismail, Ahmad Faisal and khashman, Basim M. (2017) Rheological characterization of gelling polymers for pharmaceutical dosage forms. In: Conference on Biomedical and Advanced Materials (Bio-Cam) 2017, 28th-29th November 2017, Bayview Hotel, Langkawi, Malaysia. (Unpublished)

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Abstract

Objective: This study aimed to characterize several gelling polymers as candidates to be developed as pharmaceutical vehicles. Significance: This study opens up more options for pharmaceutical semi-solid vehicle formulator to choose regarding the range of gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: Five types of gelling polymers (acacia gum, methocel K100M, kelcogel LT100, lambda carrageenan, and locust bean gum) which consist of three different concentrations each, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to compare their apparent viscosities at various shear rates as well as rheological modelling. Results: At shear rates of 10 s-1, 50 s-1, and 100 s-1, 3% and 5% of kelcogel LT100 as well as 3% and 5% of methocel K100M possessed significantly the highest mean apparent viscosity (Pas). Acacia gum at concentration of 1%, 3% and 5% exhibited the lowest mean apparent viscosity (Pas) (p > 0.05). Each gel possessed different rheological modeling in different concentration, except for lambda carrageenan which possessed Ostwald De-Walele modelling in all concentrations. Among the gel with good regressions, kelcogel LT100 (1% and 5%) had the highest yield stress. Lambda carrageenan (5%) was found to be the most pseudoplastic based on its lowest flow behaviour index (n), and it also possessed the highest consistency factor (k) value. Conclusion: All the rheological profiles for each of the gels at three different concentrations were successfully characterized, analyzed and documented.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	7092/60567
Uncontrolled Keywords:	gels, rheology, viscosity, shear stress, linear viscoelasticity range, gelling polymers
Subjects:	Q Science > Q Science (General) R Medicine > RK Dentistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Mr Mohammad Nasrin Abdul Rahman
Date Deposited:	23 Jan 2018 15:37
Last Modified:	23 Jan 2018 15:37
URI:	http://irep.iium.edu.my/id/eprint/60567

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