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Analysis Of MYO1H single nucleotide polymorphism in class III malocclusion with mandibular prognathism: A preliminary study

Yahya, Siti Nazirah and Abdul Razak, Nurul Syafiqah and Abu Bakar, Noraini and Mokhtar, Khairani Idah and Kharuddin, Azrul Fazwan (2017) Analysis Of MYO1H single nucleotide polymorphism in class III malocclusion with mandibular prognathism: A preliminary study. In: 1st IIUM International Dental Conference 2017 in Commemoration of the Kulliyyah of Dentistry 10th Anniversary (1st IIDC), 6th-8th October 2017, Kuantan, Pahang. (Unpublished)

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Abstract

Introduction: Evidence suggests that several genes; including MYO1H, play an important role in the etiology of Class III malocclusion. Single nucleotide polymorphism (SNP) in marker rs10850110 (locus 12q24.11) within MYO1H gene has been associated with the incidence of mandibular prognathism (MP). MYO is a class 1 myosin that is responsible for the synthesis of Matrilin-1; an important protein involved in the formation of cartilage's extracellular matrix, hence is implicated in the formation of mandibular condyle cartilage. This study aimed to detect the presence of MYO1H (rs10850110) SNP and to determine its genotype and allele distribution in MP patient in the local population. Materials and Methods: The sample comprises of 31 patients; 14 patients from class I malocclusion (control samples) and 17 patients from class III malocclusion (MP). Cephalometric measurements were performed prior to saliva samples collection. The DNA was amplified using the specific primers for the marker rs10850110 and the genotyping was done by sequencing. Chi-square test was used to determine the over-representation of marker allele (p<0.05). Results: Presence of MYO1H SNP (rs10850110) was detected in local population analysed and the distribution of its genotype and allele could be observed. There were significant differences between allele (p=0.000) and genotype (p=0.000) frequency within control (Class I) and Class III malocclusion. Conclusion(s): Our findings are in agreement with previous studies suggesting positive influence of MYO1H (rs10850110) SNP in the incidence of MP. Further studies should be developed in order to understand the exact role and mechanism of MYO1H in different classes of malocclusions. KEYWORDS: malocclusion, mandibular prognathism, gene polymorphism, Myo1H

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 5978/60324
Uncontrolled Keywords: malocclusion, mandibular prognathism, gene polymorphism, Myo1H
Subjects: R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Depositing User: Asst Prof Dr Noraini Abu Bakar
Date Deposited: 26 Dec 2017 15:15
Last Modified: 26 Dec 2017 15:15
URI: http://irep.iium.edu.my/id/eprint/60324

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