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Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion

Nowrin, Shifat A and Basri, Rehana and Alam, Mohammad Khursheed and Jaafar, Saidi and Mokhtar@Makhtar, Khairani Idah (2017) Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion. In: 16th Annual Scientific Meeting & 18th Annual General Meeting of Malaysian Section IADR, 18th March 2017, Armada Hotel, Petaling Jaya, Selangor. (Unpublished)

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Objectives: Class III malocclusion is a dominant inherited, slowly progressive dento-skeletal disharmony. It is characterized by over growth of mandible, stunted growth of maxilla, or a combination of both. The aetiology of class III malocclusion and the role of genes in this phenotype remain indistinct. The main objective of this study was to determine the DUSP6 gene mutation in three generations of a Malaysian Malay family having class III malocclusion and to conduct their cephalometric analyses. Methods: Genetic analyses of DUSP6 gene were carried out in a family with three individuals representing three generations 30 healthy control. Cephalometric radiographs were obtained from class III malocclusion subjects and pre-determined cephalometric linear and angular measurements were performed using Romexis software. t-test was used to analyse the cephalometric measurements compared with the cephalometric norm for class III malocclusion in Malaysia. Results: a heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in all three members of the family with class III malocclusion. Whereas, no mutation found in control group. t-tests showed significant differences in angular measurements Co-Gn-B and SN-MP variables in mutation group compared to the class III malocclusion norm. Conclusions: The outcome of this study broadened the mutation spectrum of class III malocclusion and the importance of DUSP6 gene in craniofacial morphology.

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 7172/59481
Uncontrolled Keywords: Genetic Mutation, Malaysian Family, Class III Malocclusion
Subjects: R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Depositing User: Assoc Prof Khairani Idah Mokhtar
Date Deposited: 21 Nov 2017 10:09
Last Modified: 21 Nov 2017 10:09
URI: http://irep.iium.edu.my/id/eprint/59481

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