Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate

Abdul Mudalip, S. K. and Adam, Fatmawati and Jamal, Parveen and Abu Bakar, Mohd Rushdi and Amran, Nur Amelia and Sulaiman, Siti Zubaidah and Che Man, Rohaida and Mohd Arshad, Z.I. and Shaarani, Shalyda Md (2017) Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate. In: The 2nd International Conference on Materials Engineering and Nanotechnology (ICMEN2017), 12th-14th May 2017, Kuala Lumpur, Malaysia.

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Abstract

This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	2937/58987
Uncontrolled Keywords:	Cooling rates, Crystal size distributions, Crystallization process, Ethyl acetates, Mefenamic acid, Needle-like, Polymorphic forms
Subjects:	T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	12 Mar 2018 10:29
Last Modified:	17 Aug 2019 16:16
URI:	http://irep.iium.edu.my/id/eprint/58987

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