Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line

Omar, Muhammad Nor and Rahman, Siti Muneerah and Ichwan, Solachuddin J. A. and Hasali, Nor Hazwani and Rasid, Faridah Abdul and Halim, Farhana Abdul (2017) Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line. Oriental Journal of Chemistry, 33 (4). pp. 1659-1664. ISSN 0970-020X E-ISSN 2231-5039

	PDF - Published Version Restricted to Repository staff only Download (415kB) | Request a copy
	PDF (wos) - Supplemental Material Restricted to Repository staff only Download (145kB) | Request a copy
Preview	PDF (scopus) - Supplemental Material Download (220kB) | Preview

Abstract

The cytotoxicity properties of Kaempferia galanga extracts were studied. Crude extracts of the rhizome were obtained by extraction with methanol (KGM), petroleum ether (KGPE) and ethyl acetate (KGEA). Meanwhile, the essential oil (KGEO) was produced by steam distillation method. The aim of the present work was to screen the cytotoxic activity of K. galanga extracts and essential oil on cervical cancer C33A cell line. The cytotoxic activities were assessed on C33A cell line using MTT and scratch assays. Results of MTT assay showed that KGEA and KGM were the most cytotoxic at 1000 μg mL-1 with cell viabilities of 11 and 14 %, respectively. Lower cytotoxic activities were shown by KGPE and KGEO with 64 and 88 % cell viability, respectively. Meanwhile, KGEA was slightly cytotoxic at concentration of 500 μg mL-1 with cell viability of 70 %. However, all the extracts were able to inhibit or at least slow down cell growth when tested using the scratch assay. It can be concluded that K. galanga seems to have cytotoxic properties and may be used as an anticancer agent.

Item Type:	Article (Journal)
Additional Information:	5626/58879
Uncontrolled Keywords:	Kaempferia galanga, cytotoxic, cervical cancer C33A cell line.
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Prof Dr Muhammad Nor Omar
Date Deposited:	30 Oct 2017 11:47
Last Modified:	19 Mar 2018 12:01
URI:	http://irep.iium.edu.my/id/eprint/58879

Actions (login required)

View Item