Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses

Al-Mahmood, Sinan and Abdul Razak, Tariq and Che Abdullah, Shahrin Tarmizi and Nik Ahmad, Nik Nur Fatnoon and Mohamed, Abdul Hadi and Al-Ani, Imad Matloub Dally and Almola, Ehsan M.A. (2017) Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses. Latin American Journal of Pharmacy, 36 (11). pp. 2278-2284. ISSN 0326-2383 E-ISSN 2362-3853

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Abstract

This study investigated the safety of concurrently administering different therapeutic doses of gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into five groups. Four drug regimens, using therapeutic doses calculated from human doses scaled by body surface area, were administered and any effects on kidney and liver biochemical parameters and histopathology were determined. Concurrent therapeutic administration of GBP and CBZ at high doses may produce adverse effects, but maintaining a moderate dose appears safe and may be appropriate, causing fewer side effects than high doses of a single drug or high dose combination therapy. Considera- tion should be given to the total drug load than to the individual doses of each medication. Combining GBP and CBZ in a specific ratio may enable the doses of each to be reduced, which may reduce adverse effects from combination treatments.

Item Type:	Article (Journal)
Additional Information:	7037/58694
Uncontrolled Keywords:	Carbamazepine, Concurrent, Gabapentin, Moderate therapeutic doses, Safety
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User:	Mr SINAN AL-MAHMOOD
Date Deposited:	29 Nov 2017 15:24
Last Modified:	08 Dec 2017 15:51
URI:	http://irep.iium.edu.my/id/eprint/58694

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