Histological study on the protective effects of tamarind seed extract on cobra venom in mice

Al-Ani, Imad Matloub Dally and Ismail, Soraya and Maung, Khin Maung and Syed Ahmad, Pakeer Oothuman and Abdullah, Sinan Mohamed (2017) Histological study on the protective effects of tamarind seed extract on cobra venom in mice. Asian Journal of Pharmaceutical and Clinical Research, 10 (10). pp. 301-305. ISSN 0974-2441 E-ISSN 2455-3891

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Abstract

Objective: Tamarind (Tamarindus indica) has been used as a medical plant for treating many human and animal diseases and widely used as a traditional herbal medicine for the treatment of snake bites. The objective of the study is to investigate whether tamarind seed extract (TSE) has neutralization activity on an adverse histological reaction against venoms of the King Cobra. Methods: A total of 20 healthy mature male mice were randomly divided into 4 groups with 5 mice in each. The control group was injected with 1 ml of normal saline. The second group was injected subcutaneously with a single dose of 24.96 µg/20 g King Cobra venom (KCV) solution. The third group was injected with the same dose of KCV solution and 10 mg/20 g of TSE. The fourth group was injected with the same dose of KCV solution and 15 mg/20 g TSE solution. The animals were sacrificed after 24 hrs of injection of the solution. Fragments of muscle, kidney, and liver were fixed in 10% neutral buffered formalin and processed for light microscopical studies. Results: The result showed that TSE reduced the histopathological changes induced by the KCV in the muscles, livers, and kidneys, and the improvement was proportional to the applied dose of the TSE indicating that TSE prevents adverse histological changes in the muscle, liver, and kidney. Conclusion: The present study demonstrated that TSE reduced the histopathological changes in the muscle, liver, and kidney induced by KCV in mice.

Item Type:	Article (Journal)
Additional Information:	5849/58693
Uncontrolled Keywords:	Histological effect, Tamarind seed, Cobra venom
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User:	Mr SINAN AL-MAHMOOD
Date Deposited:	09 Oct 2017 10:07
Last Modified:	16 May 2018 17:10
URI:	http://irep.iium.edu.my/id/eprint/58693

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