Genetic underpinnings in Alzheimer’s disease – A review

Moustafa, Ahmed A. and Hassan, Mubashir and Hewedi, Doaa H. and Hewedi, Iman and Garami, Julia K. and Al Ashwal, Hany and Zaki, Nazar and Seo, Sung-Yum and Cutsuridis, Vassilis and Angulo, Sergio L. and Natesh, Joman Y. and Herzallah, Mohammad M. and Frydecka, Dorota and Misiak, Błażej and Salama, Mohamed and Mohamed, Wael Mohamed Yousef and El Haj, Mohamad and Hornberger, Michael (2017) Genetic underpinnings in Alzheimer’s disease – A review. Reviews in the Neurosciences, 29 (1). pp. 21-38. ISSN 0334-1763

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Abstract

In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.

Item Type:	Article (Review)
Additional Information:	7497/58623
Uncontrolled Keywords:	AChE; Alzheimer’s disease; amyloid-β; APP; BChE; genetics; presenilin; prevalence vs. penetrance of genes.
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	03 Oct 2017 12:19
Last Modified:	27 Apr 2018 17:18
URI:	http://irep.iium.edu.my/id/eprint/58623

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