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α-Glucosidase inhibitory activity of selected Malaysian plants

Mohd Bukhari, Dzatil Awanis and Siddiqui, Mohammad Jamshed Ahmad and Shamsudin, Siti Hadijah and Rahman, Md. Mokhlesur and Mat So'ad, Siti Zaiton (2017) α-Glucosidase inhibitory activity of selected Malaysian plants. Journal of Pharmacy And Bioallied Sciences, 9 (3 (June-September 2017)). pp. 164-170. ISSN 0975-7406

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Diabetes is a common metabolic disease indicated by unusually high plasma glucose level that can lead to major complications such as diabetic neuropathy, retinopathy, and cardiovascular diseases. One of the effective therapeutic managements of the disease is to reduce postprandial hyperglycemia through inhibition of α-glucosidase, a carbohydratehydrolyzing enzyme to retard overall glucose absorption. In recent years, a plenty of research works have been conducted looking for novel and effective α-glucosidase inhibitors (AGIs) from natural sources as alternatives for the synthetic AGI due to their unpleasant side effects. Plants and herbs are rich with secondary metabolites that have massive pharmaceutical potential. Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against α-glucosidase enzyme. Malaysia is a tropical country that is rich with medicinal herbs. In this review, we focus on eight Malaysian plants with the potential as AGI to develop a potential functional food or lead compounds against diabetes.

Item Type: Article (Review)
Additional Information: 6804/58365
Uncontrolled Keywords: α-Glucosidase, inhibitory activity, Malaysian plants
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr M Jamshed Siddiqui
Date Deposited: 15 Sep 2017 15:51
Last Modified: 05 Jan 2018 15:10
URI: http://irep.iium.edu.my/id/eprint/58365

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