Synthesize and characterization of putrescine sulfur analogues

Sahabudin, Adzly Hairee and How, Fiona Ni Foong and Abdul Ghani, Radiah (2017) Synthesize and characterization of putrescine sulfur analogues. ESTEEM Academic Journal, 13 (Special Issue). pp. 91-97. ISSN 1675-7939 E-ISSN 2289-4934

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Abstract

Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogue was succesfully synthesis with the expected structures.

Item Type:	Article (Journal)
Additional Information:	6467/58120
Uncontrolled Keywords:	Polyamine moiety; Putrescine-sulfur compounds; Polyamine-sulfur derivatives; Sulfur containing compounds; Structural determination
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr. Radiah Abdul Ghani
Date Deposited:	22 Aug 2017 16:00
Last Modified:	22 Aug 2017 16:00
URI:	http://irep.iium.edu.my/id/eprint/58120

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