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Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)

Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Buyong, Zunariah and Awang, Mohd Shukrimi and Md Ralib @ Md Raghib, Ahmad Razali (2017) Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste). In: Medical Research Symposium 2017, 9th August 2017, Kuantan, Pahang.

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Abstract

Introduction: A novel of injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in Orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could become a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 4820/58050
Uncontrolled Keywords: vivo evaluation of bone healing
Subjects: Q Science > QM Human anatomy
R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: Sr Che Nor Zarida Che Seman
Date Deposited: 21 Aug 2017 02:49
Last Modified: 21 Aug 2017 02:49
URI: http://irep.iium.edu.my/id/eprint/58050

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