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Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response

Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and Mohd Yusoff, Mashitah and Abdull Rasad, Mohammad Syaiful Bahari and Kumar, Anuj (2017) Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response. International Journal of Polymeric Materials and Polymeric Biomaterials, 66 (3). pp. 115-122. ISSN 0091-4037 E-ISSN 1563-535X

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Abstract

The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration.

Item Type: Article (Journal)
Additional Information: 4701/57199
Uncontrolled Keywords: Bone tissue engineering, electrospinning, hydroxyethyl cellulose, nanohydroxyapatite coatings
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr. Mohammad Syaiful Bahari Abdull Rasad
Date Deposited: 06 Jun 2017 15:40
Last Modified: 02 Aug 2017 09:36
URI: http://irep.iium.edu.my/id/eprint/57199

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