Effects of eurycoma longifolia (TAF 273) on oestrous cycle and reproductive hormones of normal rats during 14-days treatment

Ahmad, Nur Amalina and Abdul Rahman, Suzanah and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, 'Afif Raihan and Chan, Kit-Lam (2016) Effects of eurycoma longifolia (TAF 273) on oestrous cycle and reproductive hormones of normal rats during 14-days treatment. In: KAHS Research Week (KRW) 2016 in conjunction with 1st Allied Health Scientific Colloquium (AHSC) 2016, 21 - 25 November 2016, KAHS Examination Hall & ​Lecture Hall 1. (Unpublished)

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Abstract

Objectives/Research Problem: Eurycoma longifolia is one of the plants used to enhanced male reproductive functions but little is known for its effect on the female reproductive system and functions. Therefore, this work is performed to study the effects of standardized extract of Eurycoma longifolia, TAF 273, on oestrous cycle and some reproductive functionality in rats. Materials and Method: Female Sprague-Dawley rats (7-8 weeks old) weighing between 170-200 g were used in this study. Vaginal smear of each rat was monitored daily for 2-weeks period (cover 3 cycles) in order to select females with normal cycle (4-5 days). Those with regular cycle were randomized into four groups of 6 animals each. Rats in the treatment group received the extract orally at different doses (50, 75 and 100 mg/kg body weight) for 14-days, whereas the control group received an equal volume of distilled water in a similar manner. The oestrous cycle pattern of both control and treatment groups were monitored daily and recorded during the 14-days treatment. The body weight of the females was recorded before and after 14-days treatment. At the end of the experiments, blood samples were collected and the serum were analysed for testosterone, oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels. Ovaries were removed, weighed and examined for histomorphological changes. Results and Discussion: The results showed that the administration of TAF 273 has some changes on the analysed variables. Conclusion: The data obtained did not indicate that Eurycoma longifolia standardized extract exhibited any detrimental effects on the oestrous cycle, ovarian histomorphology and female reproductive hormones.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	4493/56843
Uncontrolled Keywords:	Eurycoma longifolia, TAF 273, oestrous cycle, reproductive hormones, ovary
Subjects:	R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Prof. Dr. Suzanah Abdul Rahman
Date Deposited:	09 May 2017 14:49
Last Modified:	09 May 2017 14:49
URI:	http://irep.iium.edu.my/id/eprint/56843

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