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Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats

Ahmad, Nur Amalina and Abdul Rahman, Suzanah and Chan, Kit-Lam and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, 'Afif Raihan (2017) Effects of Eurycoma longifolia standardized extract on Estradiol valerate-induced teratogenicity in female rats. In: ASIA International Multidisciplinary Conference (AIMC 2017), 1st-2nd May 2017, Johor Bharu, Johor. (Unpublished)

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Estradiol valerate, a synthetic and steroidal estradiol is used as prescription for the treatment of certain female reproductive disorders as well as contraceptive drugs. Consumption of estradiol valerate during early pregnancy may produce abortional effects especially in cases of unknown pregnancy. Teratogenic effects have also been detected at toxic levels of the agent. This study therefore aims to investigate the possible effects of standardized extract of Eurycoma longifolia, TAF 273, on foetus development in female rats exposed to estradiol valerate. Pregnant female rats on day 12 of gestation (GD12) were administered with a single subcutaneous injection of estradiol valerate (0.15 mg/kg) and were randomly divided into 3 groups of 5 dams each which then received treatment of TAF 273 at doses of 25, 50 and 100 mg/kg body weight orally from day 12 gestation (GD12) until day 19 gestation (GD19). Pregnancy was terminated on day 21 of gestation (GD21) and uterus of each dam was carefully excised and the foetuses were examined for morphological observations. Results showed that exposure to estradiol valerate decreased the number of live foetuses with high number of pre-implantation loss and early resorption. Foetuses in the group treated with 100 mg/kg TAF 273 extract showed high number of live foetuses but with decreased body weight and crown-rump length as the number of embryo in the uterus also affect the availability of space for embryonic development and blood supply which relates to nutrition received by the foetuses. Observations of abnormalities in the form of kyphosis, scoliosis and kinky tail in EV group were more pronounced than in control and treatments group. The present study suggests that Eurycoma longifolia may have potential in ameliorating the teratogenic effects of estradiol valerate by reducing external abnormalities in the rat foetuses. Eurycoma longifolia may have prospective use in the treatment of female-linked disorders and complications.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 4493/56841
Uncontrolled Keywords: Eurycoma longifolia, TAF 273, Teratogenicity, Estradiol Valerate, Foetus
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Prof. Dr. Suzanah Abdul Rahman
Date Deposited: 17 May 2017 09:19
Last Modified: 17 May 2017 09:19
URI: http://irep.iium.edu.my/id/eprint/56841

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