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Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs

Sengupta, Pinaki and Chatterjee, Bappaditya (2017) Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 353-365. ISSN 0378-5173

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The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered topically through nanoemulgel. Rationality of use along with the major challenges to overcome for nanoemulgel formulation has been discussed. The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their, noninvasive drug delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future.

Item Type: Article (Review)
Additional Information: 7745/56754
Uncontrolled Keywords: Nanoemulgel; Lipophilic drugs; Topical delivery; Future scope.
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Bappaditya Chatterjee
Date Deposited: 02 May 2017 15:42
Last Modified: 26 Jan 2018 13:10
URI: http://irep.iium.edu.my/id/eprint/56754

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