Synthesis and characterization of functionalized Se-MCM-41 a new drug carrier mesopore composite

Rahman, Md. Mokhlesur and Md Aris, Mohd Aznan and Yusof, Alias Mohd and Ansaryr, H. and Siddiqui, Mohammad Jamshed Ahmad and Yusan, S. (2017) Synthesis and characterization of functionalized Se-MCM-41 a new drug carrier mesopore composite. Oriental Journal Of Chemistry, 33 (2). pp. 611-621. ISSN 0970-020X E-ISSN 2231-5039

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Abstract

Various nanocomposite materials play a number of important roles in modern science and technology including pharmaceutical science. Among these materials, mesoporous materials cover a large number of applications in drug delivery system. The quantitative incorporation and high dispersion of selenium nanoparticles into MCM-41 have been made possible by the coordination between Se(IV) ion and aminopropyltriethoxysilane (APTES)-anchored MCM-41. The samples were characterized by X-ray powder diffraction, Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), nitrogen adsorption–desorption via multi-point Brunauer, Emmett and Teller (BET) analysis, Raman spectroscopy and UV-Vis diffusion reflection spectroscopy (UV-vis/DRS). The increase in cell parameter and the decrease in surface area observed by N2 adsorption-desorption technique were taken as evidence of selenium introduction inside the MCM-41 framework. The behaviour of drug release in these nanocomposites is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.

Item Type:	Article (Journal)
Additional Information:	5269/56753
Uncontrolled Keywords:	Mesoporous materials; MCM-41; Se-MCM-41
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Mohd Mokhlesur Rahman
Date Deposited:	09 May 2017 15:02
Last Modified:	20 Sep 2017 08:47
URI:	http://irep.iium.edu.my/id/eprint/56753

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