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Nose to brain drug delivery: a recent update

Chatterjee, Bappaditya (2017) Nose to brain drug delivery: a recent update. Journal of Formulation Science & Bioavailability, 1 (1). 105 -1. E-ISSN 2577-0543

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Drugs used to treat brain or central nervous system disorder suffer from shortfall of absorption and reaching brain due to blood brain barrier and cerebro spinal fluid barrier. Intra nasal administration of brain targeted drug delivery system is gaining popularity to circumvent blood brain barrier and enhance drug availability in brain. It also shows promising reduction of systemic adverse effect incurred by the drug. However there are major limitation of this route which restrict its success of application. Despite different dosage forms such as micro or nano emulsion, gel, in situ gel etc the intra nasal route is still lacking wide applicability. This short review aims to highlight some important features related to nose to brain drug delivery along with its potential challenges that need to overcome. It has focused on few interesting or significant articles on the matter published within last 4-5 years.

Item Type: Article (Journal)
Additional Information: 6923/56686
Uncontrolled Keywords: Nose to brain; In situ gel; Intra nasal; Blood brain barrier; Nano emulsion
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Bappaditya Chatterjee
Date Deposited: 02 May 2017 10:21
Last Modified: 18 May 2018 10:52
URI: http://irep.iium.edu.my/id/eprint/56686

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