Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills

Allow, Ahmed Kaid Naji and Hellis, Ayah Rebhi and Yousef, Zainab and Mohamed Bakrim, Norbaiyah and Ahmed Kaid, Belqees and Saxena, Anil Kumar (2015) Anti-fertility potential of Trigonella foenum-graecum in comparison to oral contraceptive pills. In: Medical Research Symposium 2015, 10th Dec. 2015, Kuantan, Pahang.

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Abstract

Introduction: This study examines the anti-fertility effects of Trigonella foenumgraecum (fenugreek) seeds extract in the reproductive system of female rats in comparison to combined oral contraceptive pills (COCPs). Methods: Thirty two female Sprague Dawley rats of 8 weeks old were divided into four groups (A, B, C and D). All female rats were allowed to mate with male rats. Group A is a positive control and not given any treatment. Group B is a negative control group. Group C and D were treated with 0.05 mg/kg body weight of COCPs and 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days respectively. Blood samples were subsequently taken on the proestrous phase to evaluate the serum levels of follicular stimulating hormone (FSH). The embryo implantation rate was studied in all groups. Results: Administration of 750 mg/kg FSA extract and COCPs both resulted in decreased FSH serum levels, to 25.62 ng/ml and 71.56 ng/ml respectively (p<0.01). The embryo implantation rate was zero in both FSA extract and COCPs treated groups. Conclusions: Anti-fertility effects of FSA extract and COCPs are potentially similar in terms of their ability to reduce FSH serum levels and inhibit implantation.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	6774/56474
Uncontrolled Keywords:	Anti-fertility, Trigonella foenum-graecum, COCPs, Endometrial Thickness
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	ahmed kaid allaow
Date Deposited:	04 May 2017 16:02
Last Modified:	04 May 2017 16:02
URI:	http://irep.iium.edu.my/id/eprint/56476

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