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Model of a critical size defect in the New Zealand White rabbit’s tibia

Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Mohamed Amin, Mohamed Azril and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2016) Model of a critical size defect in the New Zealand White rabbit’s tibia. The International Medical Journal Malaysia ( IMJM ), 15 (Supplement Issue). p. 43.

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Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study. Results: This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New Zealand White rabbits.

Item Type: Article (Journal)
Additional Information: 3447/55462
Uncontrolled Keywords: New Zealand white rabbit, critical size defect, surgical approach, bone healing
Subjects: R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: Assoc. Prof Mohd Shukrimi Awang
Date Deposited: 24 Feb 2017 10:10
Last Modified: 19 Oct 2017 10:20
URI: http://irep.iium.edu.my/id/eprint/55462

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