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Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells

Rostam, Muhamad Ashraf and Piva, Terence J. and Osman, Narin and Little, Peter J. (2013) Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells. In: The 2013 Joint Meeting of AVBS & ANZMS, 5th-8th Sept. 2013, Novotel Resort, Barossa Valley, South Australia, Australia. (Unpublished)

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Abstract

The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. In vascular smooth muscle cells (VSMC) GAG chain hyperelongation is dependent upon transcription and translation but the targets of TGF-β signalling, most likely genes for GAG enzymes, remain unknown. A recent study by Anggraeni et al showed that GAG enzymes C4ST-1 and ChGn-2 involved in chondroitin sulphate (CS) GAG elongation have higher levels of expression in a mouse model of atherosclerosis.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 7744/55300
Uncontrolled Keywords: proteoglycan glycosaminoglycan (GAG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User: Dr Muhamad Ashraf Rostam
Date Deposited: 25 Apr 2017 12:11
Last Modified: 25 Apr 2017 12:12
URI: http://irep.iium.edu.my/id/eprint/55300

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