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Cyclin dependent Kinases as potential therapeutic targets for atherosclerosis

Rostam, Muhamad Ashraf and Piva, Terence J. and Osman, Narin and Little, Peter J. (2015) Cyclin dependent Kinases as potential therapeutic targets for atherosclerosis. In: 78th Harden Conference: Protein Kinases in Health and Disease, 15th—18th September 2015, Winchester, United Kingdom. (Unpublished)

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Abstract

Cardiovascular disease is the leading cause of death among adults worldwide and atherosclerosis is the major underlying pathology. The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyper-elongation that results in increased proteoglycan (PG) binding to low density lipoprotein (LDL). Elevated GAG synthesizing enzyme mRNA expression has been shown to be linked to in vivo atherosclerosis development. Transforming Growth Factor-β (TGF-β) is associated with atherosclerosis and mediates GAG chain hyper-elongation. The specific GAG synthesizing enzymes and the signalling pathways are unclear. TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also lead to other serine/threonine kinases, including ERK, to phosphorylate Smad2 in the linker region. This leads to TGF-β mediated PG hyper-elongation in human vascular smooth muscle cells (VSMC). Little is known regarding the involvement of CDK in TGF-β mediated PG synthesis in human VSMC. Understanding this signalling pathway facilitates the identification of a therapeutic target to prevent atheroslcerosis

Item Type: Conference or Workshop Item (Poster)
Additional Information: 7744/55255
Uncontrolled Keywords: Cyclin dependent Kinases, therapeutic targets, atherosclerosis
Subjects: R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User: Dr Muhamad Ashraf Rostam
Date Deposited: 20 Apr 2017 09:53
Last Modified: 20 Apr 2017 09:53
URI: http://irep.iium.edu.my/id/eprint/55255

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