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The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats

Abdul Rahman, Suzanah and Ahmad, Nur Amalina and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, 'Afif Raihan and Chan, Kit-Lam (2017) The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats. Asian Pacific Journal of Tropical Biomedicine, 7 (1). pp. 27-31. ISSN 2221-1691

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Abstract

Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days. Vaginal smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological changes. Results: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ovaries. Conclusions: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility.

Item Type: Article (Journal)
Additional Information: 4493/55093
Uncontrolled Keywords: Eurycoma longifolia; Oestradiol; Oestrous cycle; Ovaries; Progesterone; Testosterone
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Assoc. Prof. Dr. Suzanah Abdul Rahman
Date Deposited: 02 Feb 2017 15:22
Last Modified: 06 Jun 2017 12:41
URI: http://irep.iium.edu.my/id/eprint/55093

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