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Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using ICING model

Jamaludin, Ummu Kulthum and Suhaimi, Fatanah M. and A. Razak, Normy N. and Md Ralib, Azrina and Mat Nor, Mohd. Basri (2016) Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using ICING model. In: International Conference on Computer, Communication, and Control Technology (I4CT 2014), 2nd-4th Sept. 2016, Langkawi, Kedah, Malaysia. (Unpublished)

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Abstract

The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathematical equations defined in ICING model to find critical parameters of insulin sensitivity (SI) and results of total endogenous insulin secretion and total plasma insulin level were presented in median and 95% confidence interval (CI). It is reported that the total median plasma insulin is 1.35 x 106 mU while (6.59 x 105, 2.79 x 106) mU is in 95% CI, and the total median endogenous insulin secretion is 12.9% from the total median plasma insulin. The results elucidated the effectiveness of current practice via Intensive Insulin Infusion Therapy (IIT) and also suggest a further study on investigating the incretin mechanism which is strongly believed to contribute to the total plasma insulin level and help to simulate endogenous insulin secretion

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 3934/54923
Uncontrolled Keywords: ICING Model, Endogenous Insulin, Exogenous Insulin, Plasma Insulin, Critically Ill.
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User: Dr Azrina Md Ralib
Date Deposited: 17 May 2017 09:29
Last Modified: 17 May 2017 09:29
URI: http://irep.iium.edu.my/id/eprint/54923

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