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In vitro evaluations of anti-hyperglycemic ant antioxidant activities of Entada spiralis Ridl. stem bark extracts

Bukolami, Fatimah and Mat So'ad, Siti Zaiton and Ahmed, Qamar Uddin and Mohd. Hassan, Norazian (2016) In vitro evaluations of anti-hyperglycemic ant antioxidant activities of Entada spiralis Ridl. stem bark extracts. In: 3rd Pan-Asian Biomedical Science Conference 2016 Kuala Lumpur, 7th–8th Dec. 2016, Kuala Lumpur, Malaysia. (Unpublished)

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Abstract

Entada spiralis Ridl. (leguminoceae), locally known as “Sintok” or “ Beluru” is a woody climber that grows widely in Malaysia. Phytoconstituents of various crude extracts obtained from solvents of varying polarities were analyzed. The antioxidant and antihyperglycemic potentials of the extracts were assessed using DPPH, ABTS and α-glucosidase inhibitory methods respectively. Qualitative analysis shows the presence of most of the phytochemicals in methanol extract with chloroform and petroleum ether having terpenoid and tannins as their major constituent respectively. Methanol extract contains highest amount of total phenolics and flavonoids (42.5 ±15.85, 28.94±2.93). This extract also shows a very high α-glucosidase inhibitory activity with IC50 value of 20.67. Chloroform and methanol extracts exhibited good radical scavenging activities dose dependently. This result suggests the medicinal potential of Entada spiralis Ridl. stem bark as a therapeutic agent against hyperglycemia and free radical associated problems, the potential which may be attributed to the presence of terpenoid, phenolics and flavonoids.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 5652/54540
Uncontrolled Keywords: Entada spiralis: phytoconstituents: polarities: antioxidants: hyperglycemia
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Siti Zaiton Mat So'ad
Date Deposited: 14 Feb 2017 12:16
Last Modified: 14 Feb 2017 12:16
URI: http://irep.iium.edu.my/id/eprint/54540

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