Khan Chowdhury, Ahmed Jalal and Helal Uddin, A.B.M. and John, Akbar and Bulbul, Mahbuba and M. N., Nur Hafizah
(2016)
Persistence of chloramphenicol in the fish flesh patin (Pangasius hypothalamus) and tilapia (Oreochromis niloticus).
International Medical Journal of Malaysia, 15 (supplement).
p. 110.
ISSN 1823-4631
Abstract
Introduction: Increasing antibiotic resistance in bacteria is a serious global problem. This
study was aimed to extract the antibiotic Chloramphenicol (CAP) from different parts of
the fish flesh. Methods: Fish fleshes were excised from two commercially important
fishes: Oreochromatis niloticus.(Red Tilapia) and Pangasius hypothalamus (Patin). The
fleshes were chosen form head and tail region where generally antibiotics are spiked to
avoid bacterial contamination while kept in cold storages of supermarkets. Each fish
fleshes were weighed and spiked with 20,40,80 and 160ppm of CAP and stored at 4°C.
The CAP residue from the flesh was extracted immediately after the first spiking
was considered as Day-1. The whole extraction processes were done for 1,7,14 and 28
days. HPLC (High Performance Liquid Chromatography) was used to determine the
presence of CAP residue in the tested fish flesh. Results: The results showed variations on
the percentage of antibiotic residue recoveries at different concentration. In this study,
CAP did not degrade and showed variations on the presence of antibiotic residue in the
fish flesh. The recoveries of the entire CAP spiking samples ranged from 4.0% -100%. It also
revealed the presence of antibiotic residue in Malaysian freshwater cultured fishes. Thus,
the relevant authorities should take immediate action regarding this issue in order to
prevent the harmful effects especially to human. Conclusions: Nevertheless, the study
portrays that antibiotic residues can be sustained long time in the food products under
storage conditions, which might have harmful effects on human when they consumed
these frozen fishes.
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