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Synthesis and characterization of spermidine containing sulphur

Sahabudin, Adzly Hairee and How, Fiona Ni Foong and Abdul Ghani, Radiah (2016) Synthesis and characterization of spermidine containing sulphur. In: 13th Universiti Malaysia Terengganu International Annual Symposium on Sustainability Science and Management (UMTAS 2016), 13th-15th Dec. 2016, Kuala Terengganu.

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Abstract

Studies in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for their anti-cancer properties. The polyamine transport system however is known for its ability to interact with cancer cells directly. By adding sulphur to known natural polyamine, the resulting compound is anticipated to retain both properties. One of the widely used of polyamine moiety is used as the cell delivery vector to transport sulphur to the targeted cancer cells. In this study, the spermidine containing sulphur was synthesized by adding carbon disulphide atoms to spermidine atom. The compound was then characterized and analyzed to determine its physiochemical properties and chemical structure. Determination on the characteristic and chemical structure of the compounds were carried out using various techniques such Fourier transformed infrared spectroscopy, thin layer chromatography and gas chromatography mass spectroscopy.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 6467/53900
Uncontrolled Keywords: Spermidine, polyamine moiety, compound containing sulphur, structural determination, organosulphurs
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Radiah Abdul Ghani
Date Deposited: 10 Jan 2017 15:43
Last Modified: 17 May 2017 14:26
URI: http://irep.iium.edu.my/id/eprint/53900

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