α-glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and lc–ms/ms profiling of the active cultivar

Lawal, Umar and Leong, Sze Wei and Shaari, Khozirah and Ismail, Intan Safinar and Khatib, Alfi and Abas, Faridah (2016) α-glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and lc–ms/ms profiling of the active cultivar. Journal of Food Biochemistry. pp. 1-8. ISSN 1745-4514 (In Press)

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Abstract

The present study was designed to investigate the effect of Ipomoea aquatica extracted using water and methanol at various concentrations on the total phenolics, antioxidant capacity, and a-glucosidase inhibitory activities. Three I. aquatica cultivars were used in this study including the upland type with narrow leaves (K-11), low-land aquatic types with broader shaped leaves (K-25), and bamboo-shaped leaves (K-88). The results revealed that 70% methanol extract of K-11 showed higher total phenolic content and a-glucosidase inhibitory and antioxidant activities than the other two cultivars. The phytochemical constituents in the active extract K-11 were analyzed by means of liquid chromatography coupled with diode array detection and electrospray tandem mass spectroscopy. Eighteen compounds were detected of which 13 were tentatively identified as quercetin-3-O-sophoroside, quercetin-3-O-glucoside, quercetin-3,7-di-O-glucoside, nomilinic acid glucoside, 4,5-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, luteolin-7-glucoside and 3,4,5-tricaffeolquinic acid, fatty acid together with quercetin, and tricaffeoylquinic acid derivatives.

Item Type:	Article (Journal)
Additional Information:	6915/53526
Uncontrolled Keywords:	α-glucosidase, inhibitory, antioxidant, ipomoea aquatica cultivars, lc–ms/ms, cultivar
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	13 Dec 2016 18:18
Last Modified:	13 Dec 2016 18:21
URI:	http://irep.iium.edu.my/id/eprint/53526

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