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Preclinical evidence of Malay traditional herbal supplement for diabetes

Abdul Majid, Fadzilah Adibah and Teh, L. C and Sayid Abdullah, S.H.A and Ahmad, Rabiatul Adawiyah and Bakhtiar, M. Taher and Abdul Wahid, Mohd Effendy (2016) Preclinical evidence of Malay traditional herbal supplement for diabetes. In: V World Congress on Medicinal and Aromatic Plants (WOCMAP) and International Symposium on Plants, as Factories of Natural Substances, Edible and Essential Oils, 17th-22th Aug. 2014, Brisbane, Australia.

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In this report, one herbal folk recipe traditional claim for diabetes treatment, jamu KM is subjected to scientific studies. The exposure of traditional diabetes decoction, KM extract to 3T3-L1 at 1 mg mL-1 shows significant increase in glucose uptake with no LD50 value. 150 μg mL-1 methanolic extract of Jamu KM yield intense lipid droplet accumulation in non-insulin induced adipocytes 3T3-L1. Further investigation through in vivo study of KM extract using diabetic Spraque Dawley rats indicates reduction in blood glucose at the concentration of 0.05 g kg-1 body weight (bwt). A similar response was observed with the treatment using glibenclamide at 0.006 g kg-1 bwt. Histopathological data show increase in the relative organ weight (g 100 g-1 bwt) of liver and kidney of all diabetic rats as compared to normal group while pancreas was not affected. However, glibenclamide treated group shows 14 and 15% larger liver and kidney, respectively, than the other diabetic groups and jamu KM treated. This finding is a promising approach in validation of herbal medication from the past wisdom through modern techniques.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 5209/53348
Uncontrolled Keywords: Malay, diabetes, jamu, KM, preclinical,validation
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Muhammad Taher
Date Deposited: 21 Dec 2016 11:00
Last Modified: 11 Oct 2017 10:04
URI: http://irep.iium.edu.my/id/eprint/53348

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