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Craniofacial morphology of class III malocclusion with DUSP6 gene: Mutation and non-mutation groups

Nowrin, Shifat A and Basri, Rehana and Alam, Mohammad Khursheed and Yusa, Tatsunori and Nakano, Junzaburo and Jaafar, Saidi and Mokhtar, Khairani Idah and Osuga, Naoto (2016) Craniofacial morphology of class III malocclusion with DUSP6 gene: Mutation and non-mutation groups. Journal of Hard Tissue Biology, 25 (3). pp. 247-256. ISSN 1341-7649

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Abstract

The etiology of developing class III malocclusion and the role of craniofacial structures in this phenotype remain indistinct. The purpose of this study was to compare the relative relationship of craniofacial structures of DUSP6 gene mutation and non-mutation groups in class III malocclusion of Malaysian Malay families and their three generations. Thirty class III cephalometric radiographs of ten Malaysian Malay families including three generations with an average age 23, 54 and 79 years of each generation respectively were studied. All landmarks were positioned, determined and consequently tracings were completed Romexis software (Planmeca, Finland) to accomplish craniofacial morphology investigation. The statistical comparisons of the mutation and non-mutation group were conducted with independent t test and analysis of variance (ANOVA) was applied to evaluate the values for three generations in class III malocclusion among all measurements. The result of the current study revealed that in mutation group, there are significant differences in Co-Gn-B and SN-MDP variables compare to non-mutation group. However, almost all craniofacial variables show no significant differences among three generations. This study may suggest that in mutation group mandible is more deviated from cranial base compare to non-mutation group and there are virtually no skeletal changes among three generations with age in case of growing class III malocclusion.

Item Type: Article (Journal)
Additional Information: 7172/52843
Uncontrolled Keywords: Cephalometric evaluation, Class III malocclusion, DUSP6 gene mutation, Malaysian Malay, Three generations
Subjects: R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Depositing User: Assoc Prof Khairani Idah Mokhtar
Date Deposited: 25 Nov 2016 11:37
Last Modified: 25 Nov 2016 11:37
URI: http://irep.iium.edu.my/id/eprint/52843

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