Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers

Keane, Kevin N and Mustafa, Kamarul Bahyah and Hinchliffe, Peter and Conceicao, Jason and Yovich, John L (2016) Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers. Reproductive BioMedicine Online, 33 (2). pp. 149-160. ISSN 1472-6483

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Abstract

To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights.

Item Type:	Article (Journal)
Additional Information:	4990/52266
Uncontrolled Keywords:	β-HCG, birthweight, FET, IVF-ET, single embryo transfer, vitrification.
Subjects:	R Medicine > RG Gynecology and obstetrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Obstetric & Gynecology
Depositing User:	salina mohammad
Date Deposited:	13 Oct 2016 10:16
Last Modified:	05 Jun 2017 11:35
URI:	http://irep.iium.edu.my/id/eprint/52266

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