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Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres

Rahman, Md. Mokhlesur and Ansary, R.H. and Mohamed, Farahidah and Kasmuri, Abdul Razak and Md. Aris, Mohd. Aznan and Katas, H and Awang, M.B. (2016) Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres. In: International Conference on Industrial Pharmacy (2nd ICIP 2016), 15th-16th Aug. 2016, Kuantan, Pahang. (Unpublished)

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Abstract

Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system still suffer from two major technical problems associated with their inherent stability problem [3]. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. Many strategies have been explored currently to reduce the high initial burst release of protein and peptide drugs from PLGA microspheres [4]. Fabrication of double-walled microspheres in which protein drugs encapsulated in the inner core surrounded by a drug free outer polymer layer offers a promising technique in reducing the high initial burst release. In previous studies, large size double-walled microspheres have been prepared using poly(L-lactic acid) (PLLA) and different co-polymers of PLGA (ester-terminated and carboxyl-terminated) as the core and shell material. Double-walled microspheres consisting PLLA and ester-terminated PLGA as the core or shell material required more time for the complete release of encapsulated drugs due to the slow degrading nature of these polymers.

Item Type: Conference or Workshop Item (Other)
Additional Information: 5629/52222
Uncontrolled Keywords: Controlled release, Microspheres, Poly(lactide-co-glycolide)
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr Mohd Mokhlesur Rahman
Date Deposited: 12 Oct 2016 14:33
Last Modified: 12 Oct 2016 14:33
URI: http://irep.iium.edu.my/id/eprint/52222

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