Prevalence, clinical features and factors associated with psychosis among Idiopathic Parkinson’s disease (IPD) patients in Universiti Kebangsaan Malaysia Medical Centre (UKMMC)

Md Rosli, Najwa Hanim and Abdul Rahman, Abdul Hamid and Mohamed Ibrahim, Norlinah (2016) Prevalence, clinical features and factors associated with psychosis among Idiopathic Parkinson’s disease (IPD) patients in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3rd-5th August 2016, Kuantan, Pahang. (Unpublished)

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Abstract

Intro: This was a cross sectional study of the prevalence of psychosis and its characteristic in patients with Idiopathic PD (IPD) attending neurology clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Methods: Assessment were done using a structured demographic data and clinical information questionnaire, Mini-International Neuropsychiatric Interview (MINI) 6.0.0, Starkstein’s Apathy Scale (AS), Mini Mental State Examination (MMSE), Movement Disorder Society – Unified Parkinson Disease Rating Scale (MDS-UPDRS) Q1-Q6, Hoehn and Yahr (H&Y) stages of PD and Schwab and England Activities of Daily Living (ADL) scale. Results: 112 patients were studied. Psychosis was identified in 39 (34.8 %) patients (33 patients with hallucination only, 6 with hallucination and delusion (psychotic disorder) and none with delusions only). Among patients experiencing hallucinations, 14 (35.9%) had visual hallucination only, 12 (30.8%) had auditory hallucinations only, and 13 (33.3%) had both visual and auditory hallucinations. Psychosis were more common in IPD patients with cognitive impairment using MDSQ1 scoring (OR 0.15; 95% CI, 0.05-0.63; P = p‹0.05) while others variables were not significant. The analysis between patients with psychotic symptoms only and patients with psychotic disorder showed education level (p<0.05), duration of illness (OR 1.8; 95% CI, (-10.7 - -3.5; p <0.01), cognitive impairment score - MDSQ1 (OR 0.2; 95% CI, 0.2-0.9; p<0.01), H&Y score (OR 0.4; 95% CI, -2.1- -0.6; p<0.01) and ADL score (OR 0.6; 95% CI,0.3 – 2.6; p<0.05) were significant. Conclusion: Lower education level, longer duration of illness, more advance stage of Parkinson disease and less functioning in ADL were significant in psychotic disorder in IPD.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5698/52218
Uncontrolled Keywords:	Idiopathic Parkinson disease, psychosis, psychiatry, neuropsychiatry
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Dr Najwa Hanim Md Rosli
Date Deposited:	11 Oct 2016 16:01
Last Modified:	24 May 2018 11:39
URI:	http://irep.iium.edu.my/id/eprint/52218

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