Prevalence of thyroid dysfunction in East and West Coast of Malaysia

Shahar, Mohammad Arif and Saud Gany, Siti Liyana and Omar, Ahmad Marzuki and Abdul Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2016) Prevalence of thyroid dysfunction in East and West Coast of Malaysia. In: 7th MEMS Annual Congress, 19-22 May 2016, Kuala Lumpur.

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Abstract

Objectives. To determine the prevalence of thyroid dysfunction in the coastal communities of Malaysia. This study is part of a nationwide study looking into the prevalence of thyroid disorders. Methods. A cross sectional study was performed in Tanjong Karang and Kuala Selangor, Selangor - two coastal villages in rural West Coast (WC) and Kuantan, Pahang - a city in the East Coast (EC) of Malaysia. A participant from each household from each villages/city was selected using KISH tables. Sociodemographic data, medical history, anthropometric measurements were recorded. Blood withdrawn was tested for thyroid function test. Serum thyroid stimulating hormone (TSH) was measured using a third generation chemiluminescent immunoassay with a detection limit of 0.01 mIU/L. TSH level of less than 0.32 mIU/L was considered hyperthyroid. Hypothyroidism was defined as TSH level of more than 5.00 mIU/L. Results. A total of 904 subjects were recruited with a mean age of 46.3 ± 16.3 years. Majority were Malays (88.0%), followed by Indians (7.7%) and Chinese (3.7%). Four hundred and fifteen (415) respondents were from the WC community and 489 respondents were from the EC community. The respondents from the EC was significantly younger compared to those from the WC (54.1 ± 14.1 versus 39.6 ± 15.1 years, p < 0.001). A total of 895 blood samples were available for thyroid level assessment. The prevalence of overt and subclinical hypothyroidism in both coastal communities was 3.4 and 13.4 per 1000 population respectively. On the other hand, the prevalence of overt and subclinical hyperthyroidism was 3.4 and 26.8 per 1000 population respectively. There was no significant difference between the prevalence of thyroid dysfunction between the WC and EC population. Overall, female has higher prevalence of thyroid dysfunction compared to male in both areas. Conclusion. The prevalence of overt hyperthyroidism and hypothyroidism was 3.4 per 1000 population each. The low prevalence of thyroid dysfunction in the West and East Coast communities could be attributed to the iodine sufficient status in those areas.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	5471/52069
Uncontrolled Keywords:	Prevalence, thyroid dysfunction, Malaysia
Subjects:	R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Mohammad Arif Shahar
Date Deposited:	05 Oct 2016 17:21
Last Modified:	17 Oct 2016 10:09
URI:	http://irep.iium.edu.my/id/eprint/52069

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