CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia

Ngow, Harris Abdullah and Wan Khairina, Wan Mohd Nowalid and Teh , Lay Kek and Lee, Wee Leng and Harun, Roslan and Ismail, Rusli and Salleh, Mohd Zaki (2009) CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia. Singapore Medical Journal, 50 (5). pp. 490-493. ISSN 0037-5675

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Abstract

Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realising the importance of inter-individual differences in the genetic profile in determining the outcome of a drug therapy, this study was conducted to explore the types and frequencies of CYP2C9 alleles in healthy and warfarin-treated Malays and Chinese, the two major ethnic groups in Malaysia. We aimed to evaluate the prevalence of the types and frequencies of common CYP2C9 alleles (*1, *2, *3 and *4) among the healthy unrelated individuals and diseased patients prescribed with warfarin.

Item Type:	Article (Journal)
Additional Information:	4393/5194
Uncontrolled Keywords:	CYP2C9 frequency, Genetic polymorphism, Pharmacogenomics testing, Warfarin
Subjects:	R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Associate Professor Dr Harris Ngow Abdullah
Date Deposited:	28 Oct 2011 15:57
Last Modified:	18 Nov 2011 10:10
URI:	http://irep.iium.edu.my/id/eprint/5194

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